The motivation for our work is derived from clinical problems in the treatment of Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI). Using basic neurobiological techniques, we want to understand the mechanisms of the underlying pathophysiology in degenerative and traumatic CNS disorders. In a translational approach, our group works on the identification of biomarkers and novel therapeutic approaches for neurodegenerative disorders.